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In contrast, induction of ER stress via central administration of thapsigargin completely abolished the RYGB-mediated improvement in leptin sensitivity, without affecting control animals, highlighting ER stress as a key regulatory factor in the beneficial effects of RYGB on hypothalamic leptin signaling [97]
Prostatitis: Inflammation or infection of the prostate gland, known as prostatitis, can cause a significant rise in PSA levels
Cytoscape version 3.7.1 (Reference Cline, Smoot and Cerami25) and the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database (Reference Szklarczyk, Franceschini and Wyder26) were used to construct a proteinprotein interaction network to obtain known and predicted protein interactions
These cardiovascular benefits extend beyond the weight loss itself, suggesting direct metabolic effects from the medication
