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A clinical trial with 2,000 adults without diabetes who took weekly semaglutide injections with a healthy diet and exercise found that: Participants lost an average of 4% of their initial body weight after 8 weeks on semaglutide

For instance, semaglutide and liraglutide, two GLP-1RA agonist drugs, have been associated with weight loss and body weight maintenance ( Figure 1 The present review aims to elucidate and describe the molecular mechanisms of the GLP-1RA drugs, semaglutide and liraglutide, and their effectiveness and potential as a therapeutic option against obesity

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Lancet 310 , 375377 (1977)