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These studies reported preventive impacts of polyphenols in brain oxidative stress of AD mice after the administration of different polyphenols, such as GA (100 mg/kg, p.o., for 112 days), CGA (80 mg/kg, p.o., for 16 weeks), which increase the level of glutathione peroxidase, superoxide dismutase, and catalase as three antioxidative stress enzymes in the brain of in the high-fat diet (HFD)-fed rat and transgenic mice respectively [20, 23], and resveratrol (60 mg/kg, p.o., for 24 weeks) in obesity-related AD mice at the age of 6-weeks-old [34]

The upcoming SURMOUNT-MAINTAIN trial, expected to report results around mid-2026, will specifically compare the 5 mg maintenance dose against higher doses for weight maintenance after initial loss

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Visualise your drug levels: Use the Zepbound pharmacokinetic calculator to see how drug levels build and stabilise across your full titration schedule