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Previous studies have demonstrated that the regulation of the immune system, endocrine system, and nervous system is strongly involved in the connection between the gut and the brain (Forsythe et al., 2010)

Stopping criteria: Height velocity below 4 cm/year at any mid-pubertal assessment

Bombesins The bombesin-like peptide gene family is currently comprised of 5 peptides, originating from two genes the gastrin-releasing peptide gene and the Neuromedin-B gene [21]

A prospective proof-of-concept study by Nicolau et al 19 found that liraglutide treatment for three months resulted in a decrease in BMI (from 39.3 to 35.6 kg/m 2 ), waist circumference (from 121.3 to 110.6 cm), mean Hurley stage (from 2.6 to 1.1), DLQI (from 12.3 to 9.7), Beck Depression Inventory (BDI) (from 22 to 16.7), and visual analog scale (VAS) for pain (from 5.6 to 3.2), as well as a decrease in inflammatory markers such as CRP (from 4.5 to 3 mg/dL), homocysteine (from 16.2 to 13.3 mol/L), plasma morning cortisol (from 15.9 to 12.6 g/dL), and insulin (from 18.9 to 15.7 U/mL)