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We discuss its safety & efficacy

Recent systematic reviews and meta-analyses consistently demonstrate that weight regain after GLP-1RA discontinuation is substantial and follows a characteristic trajectory, with a large proportion occurring during the early post-cessation period

It is usually a small, well-chosen combination, often built around metformin if eGFR allows, layered with an SGLT2 inhibitor and possibly a GLP-1 receptor agonist, with insulin reserved for when those options are not enough