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No clinical trial has tested the exact combination, but the closely related CagriSema (cagrilintide + semaglutide) Phase 3 trial showed that adding amylin to a GLP-1 backbone improves weight loss

15 mg of tirzepatide is 150 units at 10 mg/mL, which is more than one 1 mL syringe

Healthcare professionals who encounter patients using unlicensed peptides should approach the conversation without judgement, document use carefully, and consider appropriate baseline investigations including liver function tests, lipid profile, and renal function

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