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Cell Metab (2018) 27(4):74056

Ibrahim D, Froberg B, Wolf A, Rusyniak DE

doi: 10.1007/s13300-021-01113-y 124 SfairopoulosDLiatisSTigasSLiberopoulosE

Bidirectional regulatory contradiction: METTL3 simultaneously mediates the m 6 A modification of the 5UTR of dCK mRNA, promotes nuclear export and translation through YTHDC1, and enhances gemcitabine activation, while FTO demethylates dCK, reducing its stability, forming a balanced antagonism that promotes drug resistance/sensitization

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