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280 The accumulation of unfolded or misfolded proteins triggers the unfolded protein response (UPR), an adaptive signaling network coordinated by the endoplasmic reticulum sensors IRE1, PERK, and ATF6, which functions to restore proteostasis and maintain cellular homeostasis

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The SCN consists of a bilaterally paired cluster of 20,000 neurons that generate self-sustained oscillations of gene expression and electrical activity with a period of about 24 h

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The IGF-I and IGF-I/IGFBP-3 ratio decreased with increasing age, as reported previously [35]

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