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The drug was known to lower blood sugar and promote weight loss, but patients' livers were improving in ways that those effects alone could not explain
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TRIUMPH-4, the first completed Phase 3 trial, showed 28.7% average body weight loss at 68 weeks on retatrutide 12mg versus 2.1% on placebo, as reported by Eli Lilly in December 2025 (peer-reviewed publication pending)
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