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Although evolved solely for procaspase-1 cleavage, we confirmed that the evolved protease acquired broader caspase-like activity and processed additional death pathway substrates including caspase substrates
They significantly inhibit apoptosis, anti-inflammatory responses, protect synaptic function, promote the release of neurotrophic factors, and outperform GLP-1 single receptor agonists
Fanburg, Am
After screening abstracts and full texts, they concluded that GLP-1RA exhibit anti-inflammatory and anti-apoptotic effects across multiple organ systems, including cardiovascular, respiratory, and endocrine systems
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