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Chumakov et al., 2021
Eur J Endocrinol 171(4):R137R152
It is hypothesized by some that the zuclomiphene is responsible for some adverse effects associated with clomiphene citrate and that enclomiphene citrate is primarily responsible for the beneficial effects on hypogonadism by increasing FSH and LH
Another factor to consider is long-term benefits with weight-loss or possible disease improvement would require continued use of GLP-1 agonist in addition to other IBD treatment options, which can be an additional financial or emotional burden on patients that would need further exploring as well.
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