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Consistent topical use has been associated with improvements in the appearance of uneven tone and discoloration, suggesting that GHK-Cu copper peptide serum may help support a more balanced, refreshed-looking complexion over time

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[2] In diabetic excisional wounds, topical application outperformed PDGF-BB via Egr-1 upregulation

User experimentation suggests that longer initial treatment periods (6+ months continuous) support better benefit retention during subsequent breaks, complete discontinuation breaks of 1-2 months show acceptable benefit maintenance for most users, and very extended breaks (3-6+ months) increase risk of regression toward pre-treatment baseline particularly for short initial treatment courses