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Specifically, prolonged GLP-1RA administration (13 years or longer) has been associated with elevated thyroid cancer risk in certain populations [4], while high concentrations of liraglutide (100 nM) have been demonstrated to promote breast cancer progression via the NOX4/ROS/VEGF signaling pathway [18]

I numeri studio per studio: SURMOUNT-1 (fino a 22,5% in 72 settimane), SURMOUNT-2 (con diabete), SURMOUNT-3 (dopo intervento sullo stile di vita), SURMOUNT-4 (mantenimento) e il confronto diretto SURMOUNT-5 (tirzepatide 20,2% vs semaglutide 13,7% a 72 settimane)

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Adding retatrutide changes the metabolic environment significantly