dehydration semaglutide Maximizing Weight Loss with Semaglutide/Tirzepatide: Managing Side Effects Through Nutrition and Hydration Semaglutide Thirst: Why It Happens

Gastrointestinal side effects, such as nausea, vomiting, and diarrhea, are common with GLP-1 receptor agonists and related therapies

Genetic variations in GLP-1 receptor (GLP1R) sensitivity, FTO gene expression (appetite regulation), and MC4R pathway signaling can influence both the speed of appetite suppression and sustained fat loss

Outcomes Co-primary endpoints were percentage change in body weight from baseline to week 104 and achievement of weight loss of at least 5% of baseline weight at week 104

Wegovy does not directly affect thyroid hormones, but weight loss achieved during treatment may influence thyroid medicine requirements