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Summary Keywords metabolic myopathies, long-chain fatty acids, muscle fatigue, mitochondria, peroxisome, resistance exercise, dietary supplements, muscle pain and rhabdomyolysis Citation Negro M, Cerullo G, Parimbelli M, Ravazzani A, Feletti F, Berardinelli A, Cena H and DAntona G (2021) Exercise, Nutrition, and Supplements in the Muscle Carnitine Palmitoyl-Transferase II Deficiency: New Theoretical Bases for Potential Applications