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FIGURE 8 3.7 H 2 -rich medium improved sodium oleate-induced HepG2 cells steatosis by inhibiting inflammatory cytokines expression and pyroptosis The hepatic protection of H 2 on steatosis was further confirmed in sodium oleate (OA)-induced HepG2 cells steatosis model as indicated by Oil red O staining (Figure 9A)

In the phase 3 REDEFINE 1 trial, the combination of cagrilintide and semaglutide yielded a mean 20% reduction in body weight over 68 weeks in adults with overweight or obesity, significantly outperforming placebo and either agent alone

In this instance, reducing overall body fat through a calorie deficit may be an effective approach

Clinical trials confirmed no effect on serum IGF-1, no negative impact on carbohydrate metabolism, and excellent tolerability with safety profile indistinguishable from placebo