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Studies in animal models show consistent regenerative activity at the site of tendon injury
If needed for a clear medical indication (such as treating pellagra in a pregnant patient), niacinamide can be used with caution, but unnecessary high-dose B supplementation is avoided in pregnancy
The official reason given is safety, even though these peptides have been used safely for years and are produced by reputable compounding pharmacies
B12 deficiency is quite common in both the US and UK, affecting around 6% of people aged under 60, and nearly 20% of those 60 and over
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