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Also please keep in mind that what a biomarker is not as defined by FDA A biomarker is not an assessment of how an individual feels, functions, or survives

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For someone carrying 50 excess pounds, losing 30 pounds decreases knee joint stress by 120 poundsa clinically meaningful reduction that directly improves mobility and decreases pain signals from cartilage

[1] Chemotherapy for malignant spinal nerve sheath tumors has shown mixed results and is typically only used in patients in which surgery is not an option, or with aggressive or metastatic disease