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The liver contains GLP-1 receptors, and activation appears to directly reduce hepatic lipogenesis (fat production in the liver), increase fatty acid oxidation, and reduce inflammatory signaling in hepatocytes

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Consistently, GGCT knockdown reduced mitochondrial respiratory capacity (basal, maxillary and reserve respiration) in C4-2 cells compared with the control group (Fig

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Semaglutide inhibits gluconeogenesis, resulting in lower blood sugar levels and less circulating glucose that needs to be managed by insulin

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Hear Res 358:1021 Ghorbani A (2017) Mechanisms of antidiabetic effects of flavonoid rutin

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