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The effect took longer to manifest than hydroquinone (visible at 812 weeks vs 46 weeks), but rebound hyperpigmentation was significantly lower: only 9% of glutathione users experienced pigment return at 12 weeks post-treatment vs 38% with hydroquinone
Additionally, it has been suggested that GIPR agonists and antagonists might target different CNS receptor populations, with evidence showing that acylated peptide GIPR agonists act on GABAergic neurons to further reduce food intake and body weight when combined with GLP-1R agonists in mice 39,40
Benz F, Liebner S Structure and Function of the BloodBrain Barrier (BBB)
Aug 2020;24(15):7946-7952
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