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In addition to our included studies, there were more original studies excluded from our meta-analysis due to methodological differences and a lack of appropriate data, which provide additional support for GLP-1RAs role in reducing alcohol consumption

It should be noted that only semaglutide injection (not oral) was compared to tirzepatide, and higher doses of semaglutide were not compared to tirzeparatide.[21] The mean A1c reduction from baseline was above 2% and weight reduction was near 10 kg (22 lbs) in tirzepatide clinical studies, exceeding current FDA-approved GLP-1 products

Comparing tirzepatide versus semaglutide outcomes illustrates these differences clinically

In the context of diabetic retinopathy, Mller cells, which constitute approximately 90% of retinal glia and are critical for neuronal support [47], emerge as a key therapeutic target