Glutathione accelerates the #cellcycle & cellular reprogramming in #plant regeneration @Dev_Cell cell.com/developmental- Very pleased of this joint effort with @KenBirnbaum, Laura Lee et al, combining scRNAseq & cell cycle #PlaCCI @CBM_CSIC_UAM @b_desvoyes Glutathione accelerates the #cellcycle & cellular reprogramming in #plant regeneration @Dev_Cell cell.com/developmental- Very pleased of this joint effort with @KenBirnbaum, Laura Lee et al, combining scRNAseq & cell cycle #PlaCCI @CBM_CSIC_UAM @b_desvoyes Congratulations !
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Condensed Matter : an Institute of Physics Journal, 29 (20), Article 203002
FOXO4-DRI acts as a competitive inhibitor of this interaction binding directly to the transactivation domain 2 (TAD2) of p53, displacing FOXO4, and allowing phosphorylated p53 to be exported from the nucleus and directed to mitochondria, where it activates BAX, triggers caspase-3 cleavage (via the p53/BCL-2/Caspase-3 signalling pathway), and drives cell-intrinsic apoptosis