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The "minimal initial benefit" group (approximately 5-10% of users) reported limited improvements during treatment making discontinuation effects irrelevant, typically explained by inadequate product quality with degraded or low-concentration GHK-Cu, inappropriate application technique reducing absorption, unrealistic expectations exceeding what any topical can achieve, severe underlying pathology requiring medical intervention beyond cosmetic peptides, or individual non-responsiveness to copper peptide treatment for genetic or physiological reasons

Storage and handling Proper peptide storage directly affects potency and safety

Additionally, BPC-157 is listed as a prohibited substance under the World Anti-Doping Code (World Anti-Doping Agency [WADA], 2024)