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Gene Expression Modulation Transcriptomic analyses in cellular models have shown that GHK-Cu influences expression of a remarkably wide set of genes, with reported effects on pathways involved in: Extracellular matrix remodeling DNA repair Antioxidant response Inflammatory signaling Stem cell signaling markers This broad transcriptional footprint has been one of the most studied aspects of GHK-Cu in recent years
We circumvented the need for CYP-mediated bioactivation of AQ and DEAQ by exposing the cells to the synthetic AQ-QI and DEAQ-QI, the reactive metabolites of AQ
10.3389/fcell.2023.1167097 117 National Center for Biotechnology Information (2023a)
