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Online options may cost less but often provide uncertain medication quality, limited medical oversight, minimal side-effect support, and little to no long-term health tracking

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Because people with HIV often experience accelerated aging even when the virus is well controlled, this was a population where we might expect a metabolic intervention to register a measurable signal, so the direction was plausible

GLP-1 and GIP receptor agonists have a low intrinsic risk of causing hypoglycaemia when used alone, because their insulin-stimulating effects are glucose-dependent