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Furthermore, the authors validated the capacity of MnO 2 -coated mesoporous silica nanoparticles (MSNs) to control drug release, and the camptothecin (CPT)-loaded MnO 2 -MSNs showed sustained CPT release after the addition of GSH (Figure 1G)
This reduction in circulating toxins leads to a corresponding decrease in the production of pro-inflammatory cytokines, such as TNF-, IL-1, and IL-6
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All three mechanisms operate simultaneously, which is what makes TB-500 effective for the range of applications where it is prescribed
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