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Retatrutide Reconstitution Retatrutide reconstitution math Vial Size 5 mg BAC Water 1 mL Concentration 5 mg/mL 2 mg dose 0.4 mL (40 U) 4 mg dose 0.8 mL (80 U) 8 mg dose 12 mg dose Vial Size 10 mg BAC Water 2 mL Concentration 5 mg/mL 2 mg dose 0.4 mL (40 U) 4 mg dose 0.8 mL (80 U) 8 mg dose 1.6 mL (160 U)* 12 mg dose Vial Size 10 mg BAC Water 1 mL Concentration 10 mg/mL 2 mg dose 0.2 mL (20 U) 4 mg dose 0.4 mL (40 U) 8 mg dose 0.8 mL (80 U) 12 mg dose 1.2 mL (120 U)* Vial Size 20 mg BAC Water 2 mL Concentration 10 mg/mL 2 mg dose 0.2 mL (20 U) 4 mg dose 0.4 mL (40 U) 8 mg dose 0.8 mL (80 U) 12 mg dose 1.2 mL (120 U)* *Volumes over 1.0 mL need a larger syringe or a split injection at two sites

doi: 10.3389/fimmu.2024.1341843 Received 21 November 2023 Accepted 04 January 2024 Published 18 January 2024 Volume 15 - 2024 Edited by Ahmed Yaqinuddin, Alfaisal University, Saudi Arabia Reviewed by Suresh D

Distribute across 34 eating occasions at ~0.30.4 g/kg per meal to reach the leucine threshold that maximizes muscle protein synthesis, approximately 2.53.0 g leucine per meal for most adults and toward the upper end in older adults