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For semaglutide 2.4mg specifically, NICE technology appraisal guidance (TA875) recommends its use only within specialist weight management services, for a maximum duration of 2 years, and for adults with a BMI of at least 35 kg/m (or at least 30 kg/m with weight-related comorbidities)
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The article says tapering is safer for people whose weight goals are achieved or stabilized, whose metabolic markers have improved, and whose lifestyle habits are established
Before each injection, hold the pen up to the light and examine the solution through the viewing window
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