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In an animal model of depression and diabetes, however, exendin-4 led to antidepressant-like effects, which was associated with changes in microglial function 168

In controlled environmental settings, the rats were individually housed in plastic cages maintained at a temperature of 23 2 C, relative humidity of 55%, and exposed to a 12-h light/dark cycle

Similarly, the protective effects of metformin on subchondral bone are indirect, occuring through cartilage integrity preservation and oxidative stress reduction 54

Obesity and gallstone disease often share common risk factors including metabolic syndrome, insulin resistance, and dietary patterns