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doi: 10.1016/j.jada.2010.05.009 75 DellschaftNSRichardCLewisEDGorukSJacobsRLCurtisJMet al

The National Cancer Institute conducted chemoinformatics analysis of 60 cell lines and showed a negative correlation between xCT expression levels and sensitivity to compounds associated with GSH-mediated resistance, which indicated that xCT expression induces chemoresistance via GSH-mediated ROS detoxification activity (82)

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