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The resultant decrease in membrane permeability confines the cytotoxic activity more effectively within target cells, thereby mitigating the potent bystander effecta known contributor to on-target, off-tumor toxicity in healthy tissues expressing low levels of HER2

If researchers treat dosage as a static recipe, they can miss the reason one protocol produces a clean signal while another produces noise

This intervention helps protect cardiolipin and mitochondrial DNA from further oxidative destruction

Pentostatin also can inhibit RNA synthesis, cause DNA strand breaks, disrupt ATP-dependent cellular processes, and inhibit adenosylhomocysteinase (S-adenosylhomocysteine hydrolase), all of which also may contribute to the drug's lymphocytotoxic effects