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These metabolic improvements occur at the cellular level, meaning tirzepatide creates a calorie deficit partly through reduced intake and partly through enhanced energy expenditure
Malcon LMC, Wearick-Silva LE, Zaparte A, Orso R, Luft C, Tractenberg SG, et al
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Many preclinical studies have demonstrated that the expression of key enzymes for GSH synthesis (GCL, SLC7A11, GS) and GSSG reduction-related enzymes (G6PD, NADPH, and GR) is downregulated in myocardium exposed to pathological factors [40, 43,44,45,46,47,48,49,50]
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