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Torrioli MG, Vernacotola S, Mariotti P, et al
Renal carnitine loss may also affect the morphology and function of red blood cells and reduce the oxygen carrying and releasing capacity of red blood cells, thereby reducing tissue oxygen supply (including the kidney), and tissue hypoxia activates hypoxia-inducible factor 1 (HIF-1), which in turn reduces OCTN2 expression through the HIF-1-PPAR signaling pathway
It may offer some potential therapeutic benefits and applications
However, the specific metabolic checkpoints of the altered thresholds need further exploration, which is a future research direction
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