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The first published tirzepatide injection site reaction case involved a patient who had tolerated dulaglutide for years without reactions, then developed a severe reaction covering the entire lower abdomen after switching to tirzepatide

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J Biol Chem 249:58455850 Melndez-Hevia E, De Paz-Lugo P, Cornish-Bowden A et al (2009) A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis