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[169] In January 2024, a preliminary review conducted by the US Food and Drug Administration (FDA) confirmed no evidence had been found to suggest that the medicine causes suicidal thoughts or actions

This localized hypoxia (lack of oxygen) forces cells to switch to anaerobic energy production, generating excessive lactic acid and causing rapid, severe muscle fatigue even after minimal physical exertion

These real-world numbers are lower than clinical trial results, which is typical because trial participants receive more structured dietary guidance and follow-up

Research observations may include increased appetite, energy fluctuations and joint discomfort