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GLP-1RAs downregulate inducible NOS (iNOS) and dual oxidase 1 (DUOX1), both of which contribute to oxidative stress and epithelial damage [65, 116, 126]
3 M 3 F) were treated with doxycycline for 7 days and paired serum samples were taken pre- (D0) and post (D7) doxycyline for metabolic analysis by mass spectrometry
FIGURE 2 2.2.1 Increased endometrial glucose transporter protein 4 expression AMPK is a major energy receptor
Deregulation of these pathways is frequently observed in melasma, post-inflammatory hyperpigmentation, and senile (actinic)lentigo [154, 155, 181,182,183]
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