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Moreover, nod-like receptor protein 3 (NLRP3) inflammasome activation is highly involved in apoptotic cell death (112, 113)
Perfluorooctane sulfonate mediates GSH degradation leading to oral keratinocytes ferroptosis and mucositis through activation of the ER stress-ATF4-CHAC1 axis
For a broader overview of how these therapies work, see how GLP-1 actually supports weight loss
Interestingly and in contrast to CHAC1, CHAC2 is not localized to the mitochondria (Ward et al., 2024)
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