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This suggests that the observed activation in many brain regions is indirect likely triggered by the drug binding in more accessible areas, such as the circumventricular organs, which then transmit signals to other parts of the brain
Previous studies suggested that both PKC activation and increased intracellular Ca 2+ levels are required for TRPM5 activation [24]
It's worth noting that these protective effects are independent of GLP-1R activity because they weren't blocked by Ex 9-39
These results confirm that the cardiovascular protection seen with injectable GLP-1 agonists extends to the oral formulation, an important finding that strengthens the case for offering patients a choice of delivery method based on their preferences rather than effectiveness alone
