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So picture the tug-of-war: your biologic is working to quiet inflammation, while your fat tissue keeps refilling the tank around the clock
Breast J
Hepatocyte cultures characterise effects on glucose output (where glucagon signalling raises and incretin signalling lowers), lipogenic gene expression, mitochondrial function, and lipid oxidation pathway activation
Glucagon stimulates hepatic fat oxidation and thermogenesis, burning calories that GLP-1 alone cannot access
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