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GLP-1RA Lipid-Specific Outcomes While the GLP-1RAs used for weight loss, semaglutide and tirzepatide, have garnered much focus, multiple other GLP-1RA medications have shown positive outcomes on lipid profiles: dulaglutide has shown reduction in total cholesterol and LDL-C [65], liraglutide has shown reduction in LDL-C and ApoCIII [66], and exenatide has shown reduction in LDL-C and total cholesterol and increase in HDL-C [67]

The starting dose of 0.25 mg is designed for tolerability, and more significant weight loss typically begins after the first dose increase

On Wednesday, the FDA issued another warning calling these drugs risky and stating compounded drugs should only be used in patients whose medical needs cannot be met by an FDA-approved drug. How Can Hims & Hers Do This