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2014 (JAMA, n=54) Phase II trial in HIV with abdominal fat: significant VAT reduction over 6 months with metabolic and hepatic-signal analyses
In some patients, especially those with established retinopathy, a sharp metabolic improvement can briefly aggravate retinal findings before long-term benefit becomes clearer
It also induces nitric oxidemediated vasodilation and thus may have implications for CV disease (37, 68) and kidneys
216,217 Acquired mutations within MAPK pathway components represent a major mechanism of resistance to targeted therapy
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