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For example, GLP-1 peptides like semaglutide and tirzepatide are backed by strong clinical research
Neurological Res (2016) 38(4):3139
Retatrutide targets three hormone receptors versus one for semaglutide
On its own its effects are modest, but combined with GLP-1 the two create a synergistic effect that amplifies both glycemic control and fat reduction beyond what either achieves alone which is why tirzepatide generally outperforms semaglutide in head-to-head comparisons
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