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Improper storage could lead to vitamin degradation (losing potency) or increased risk of injection site reactions (if contaminants or precipitates form), so patients and providers should take the storage guidelines seriously
This is accompanied by the upregulation of ATP-binding cassette (ABC) transporters, such as MDR1 and MRPA, which enhance drug efflux and further contribute to resistance
Originally developed for type 2 diabetes, these drugs are now being widely used by people with obesity and metabolic syndrome to help manage weight, lower insulin resistance, and reduce cardiovascular risk
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