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Pancreatic -cells have been demonstrated to express and secrete not only GLP-1 (205, 206), but also PYY (207, 208) mini-glucagon (209) or even Xenin (210) together with glucagon (Figure 2)
Tirzepatide can reduce oral contraceptive effectiveness, necessitating backup contraception for 4 weeks after starting or increasing doses
Promoting it can lead to eating disorders, body dysmorphia and drug use
The substantial weight loss achieved with GLP-1 receptor agonists and dual GIP/GLP-1 agonistsapproximately 15% with semaglutide 2.4 mg (Wegovy) and up to 21% with higher doses of tirzepatide (Zepbound) in clinical trialsoccurs primarily through appetite suppression and reduced caloric intake rather than increased metabolic rate
