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Age-related factors Older people are at more risk because with age the production of stomach acid and intrinsic factor (a protein necessary for B12 absorption) can decrease

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Physical therapy Physical therapy is the gold standard of conservative treatment and has the strongest evidence base

She said those include: Well-designed, randomized, placebo-controlled human clinical trials for specific diagnoses (ACL tears, cartilage injuries, muscle injuries, rotator cuff tears, and so on)