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However, no major safety concerns have arisen to date, although definitive conclusions for pancreatic cancer, thyroid cancer and DRP complications cannot be drawn at this point

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Data collection For each patient, we included sociodemographic variables (age, sex), main psychiatric diagnoses according to DSM-5 [27], non-psychiatric comorbidities, and serum levels of folate (ng/ml) and vitamin B 12 (pg/ml)

Although no current evidence suggests that GLP-1RAs induce -catenin mutations or APC deficiencies, it is hypothesized that prolonged use of GLP-1RAs may foster the proliferative progression of colorectal cancer cells and pancreatic -cells, based on their mechanisms of action [99]