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NICE guidance (NG28) recommends GLP-1 receptor agonists for adults with type 2 diabetes according to specific criteria, including BMI thresholds and previous therapy response
Notably, various exendin-4-based GLP-1RAs (Exenatide: 39 aa and Lixisenatide: 44 aa), and GLP-1-based GLP-1RAs (Dulaglutide: 31 aa, Liraglutide: 31 aa, Semaglutide: 31 aa, Tirzepatide: 39 aa, and Albiglutide: 60 aa) have been developed and approved by the FDA between 2005 and 2022 for the management of T2DM (Liu, 2024)
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