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Elevated glucose and fatty acid levels in pancreatic tissue can trigger NLRP3 inflammasome, resulting in IL-1 release and subsequent -cell dysfunction and apoptosis, which ultimately contribute to the pathogenesis of T2DM (55)
DART-Seq primer beads were stored in TE-TW at 4C
In the as-treated analysis median follow-up was 1 year [0-2] for GLP-1 RA users and 1 year [13] for users of DPP-4 inhibitors
Data from similar medications shows significant weight regain within 12-18 months of discontinuation
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