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During ethanol metabolism, alcohol dehydrogenase (ADH) converts ethanol to acetaldehyde in the liver, then aldehyde dehydrogenase (ALDH2) oxidizes acetaldehyde to acetate
GI side effects may temporarily worsen during this escalation but usually resolve within 23 weeks
These gradings temper the strength of our conclusions and highlight the need for continued investigation
10.1056/NEJMoa2032183 90 YangJ.RenJ.SongJ.LiuF.WuC.WangX.et al (2013)
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