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Nef promotes neuropathology by upregulating CCL2 in microglia and enhancing IL-6 and IL-8 production in astrocytes [137,138,139], while also activating NADPH oxidase in phagocytes, thereby exacerbating neuroinflammation, myelin damage, and neuronal injury [134, 140]
Lower dosage because of enhanced bioavailability
Do I need lab work first
Enhancing GH signaling may improve sleep depth and overall recovery quality. For endurance athletes near Colorado Springs, this may be the most meaningful downstream effect
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